From Raleigh
- Take I-40 West to the Davis Drive exit (280);
- The entrance to the RTP Headquarters building will be directly across Davis Drive at the end of the exit ramp.
From Downtown Durham
- Take Highway 147 South to the Cornwallis Road exit (6);
- Take a left on Cornwallis Road;
- Take a right onto Davis Drive;
- RTP Headquarters will be on the right, just north of I-40.
From Chapel Hill
- Take I-40 East to Davis Drive exit (280);
- Take a right on Davis Drive;
- At the next traffic light, turn left into the entrance to the RTP Headquarters building.
From RTP South
- Take Davis Drive North (towards I-40);
- RTP Headquarters will be on the left, just north of I-40.
From RTP North
- Take Highway 147 South to the Cornwallis Road exit (6);
- Take a left on Cornwallis Road;
- Take a right onto Davis Drive;
- RTP Headquarters will be on the right, just north of I-40.

